A 130 kD glycoprotein attached to the cytoskeleton via its cytoplasmic domain; concentrated in areas of interneuronal contact. Its sequence contains both immunoglobulin-like domains and fibronectin type III repeats. Its close homology with NCAM suggests that it is a CAM. Like L1, F11, neurofascin and TAG-1 in vertebrate nervous systems and fasciclin II in insects, thought to be associated with the process of selective fasciculation. Sometimes GPI-anchored.

Dictionary of molecular biology. 2004.

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